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PTEK U Seminar Series

Dynamic Dissolution Testing Using TIM-1:
Applications for Understanding Mechanisms of Food Effects & pH Dependent Drug Solubility

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Date: March 22, 2012
Time: 8:30 a.m. - 9:30 a.m.
Topic: Dynamic Dissolution Testing Using TIM-1
Speaker: Dr. John E. Sagartz, President and CEO, Seventh Wave Labs
Location: WilmerHale Venture Group Office in Waltham, MA

Presentation Summary

Through its collaboration with TNO, Seventh Wave offers dynamic dissolution testing using the TIM-1 system, a computer-controlled in vitro gastrointestinal system with applications in formulation performance evaluation.  This presentation will provide a brief overview of TIM-1 and will focus on its utility in predicting the effects of food and pH on bioavailability of drugs.  Further, the presentation will describe modifications to the TIM-1 settings which enable determination of the mechanisms of these effects in vitro. 

About the Speaker

Dr. John E. Sagartz received his BS and DVM degrees from Kansas State University, followed by additional residency and research training at The Ohio State University, culminating in board certification by the American College of Veterinary Pathologists and awarding of his PhD.

Dr. Sagartz' career in the pharmaceutical industry began at Searle in Skokie, IL, followed by re-location to St. Louis, where he helped establish an exploratory preclinical development department integrating various scientific disciplines, including toxicology, pathology, ADME-PK, and pharmaceutics. At Pharmacia, Dr. Sagartz was a Science Fellow and was honored by receiving the prestigious W.E. Upjohn Award in 2001.  Dr. Sagartz left Pfizer to co-found Seventh Wave in the autumn of 2003.

Dr. Sagartz has over 20 publications in peer-reviewed journals spanning both natural and experimental disease, and frequently serves as a reviewer for scientific journals. He is a member of the American Veterinary Medical Association, the Society of Toxicologic Pathology, Society of Toxicology, American Society for Investigative Pathology and a member and Diplomate of the American College of Veterinary Pathologists.