Amorphous Solid Dispersions
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Date: July 30, 2009
Time: 8:30 a.m. - 9:30 a.m.
Location: Pharmatek Laboratories, Inc.
Speaker: Leah Appel, Ph.D., Managing Partner, Green Ridge Consulting
Presentation Summary
Improving the bioavailability of poorly soluble compounds has been a focus of much investigation over the past two decades. Amorphous solid dispersions (ASDs) are a proven approach that is applicable for many compounds. This talk focuses on understanding the key scientific and technical challenges in the manufacture and characterization of ASDs. In order to effectively formulate, process and characterize ASDs, it is important to understand both the desired properties of the material and the unit operations used to make the material. Two processes are commonly used to make ASDs at scale, hot melt extrusion and spray drying. The key factors in formulating, processing and characterizing ASDs manufactured using these processes will be presented.
About the Speaker
Dr. Leah Appel is the managing partner of Green Ridge Consulting, a pharmaceutical consulting firm specializing in formulation and process development. She has been working in the area of oral drug delivery for more than 20 years, and has applied her expertise over the entire range of drug product development, both in tailoring novel delivery technologies for clinical applications and reducing delivery technologies to practice. She is an inventor on 33 drug delivery patents and patent applications and an author on 13 publications.
Leah obtained her B.S. in Chemical Engineering from UCLA, and her doctoral degree in Pharmaceutics from the University of Utah. Prior to founding Green Ridge Consulting in 2007, she worked for 10 years at Bend Research, Inc., as the Director of Controlled Release, and for 7 years at INTERx (a division of Merck) developing controlled release technologies. She has been an active member of AAPS serving in various leadership positions. |
